The corrected formula of Creatinine clearance

Urine and serum creatinine levels are measured and the creatinine clearance rate is calculated.įormula to calculate the Creatinine clearance: Urine volume X urine creatinine/plasma creatinine.

Creatinine clearance is a measure of the glomerular filtration rate.

It is defined as the quantity of blood cleared of a substance per unit time and depends on the plasma concentration of the substance and excretion rate of the kidney which reflects GFR and renal plasma flow.

Ingestion of a large amount of meat for the time will increase the CrC.ĭefinition: GFR is defined as the number of millimeters of urine Filtrate made by the kidneys per minute.

Decreasing muscle mass will give decreased values.

Muscle mass varies among the people will also affect the CrC.

Urine collection is for 24 hours, so any error in the collection will give false results.

With each decade of life, CrC decreases 6.5 mL/min because of a decrease in GFR.

If one kidney is knocked out then another kidney is normal, can compensate for the filtration, and GFR will be in the normal limit.

The ability of filtration by glomeruli will be decreased in glomerulonephritis, acute tubular necrosis, and other primary renal diseases.

The amount of blood to be filtered is decreased in renal artery atherosclerosis, dehydration, and shock.

Most of the creatinine production is stable thorough out the day.

The daily production of creatine and creatinine depends upon the muscle mass, which fluctuates very little.

Creatinine is a breakdown of creatine phosphate which has an important role in the contraction of muscles.

Creatinine is a metabolic product of creatine-phosphate dephosphorylation in the muscles.

This is good test to assess the overall renal functional damage.

Creatinine clearance can be used to diffreneciate between the glomerular disease in comparison to diffuse chronic structural changes.In acute glomerulonephritis, it is used to follow the therapeutic response to the treatment.Dysfunction due to other causes like heart failure.This test will give information on the renal functions like:.Creatinine clearance is used to measure the glomerular filtration rate ( GFR) of the kidney.Creatinine clearance reflects the Kidneys ability to excrete creatinine.In the case of high plasma protein, creatinine secretion is increased, leading to marked overestimation of GFR.When GFR falls below 10 mL/min, the test becomes less accurate.gentamicin, heavy metals, and nephrotoxic drugs increase the creatinine level. An incomplete collection of the urine gives a false value.Exercise increases the creatinine level.Stop the medication (Drugs) like cortisone, or ACTH treatment.Avoid coffee, tea, drugs during the test.The patient should be hydrated so that there is >2 mL urine output per minute.2-hours collection preferably be done in the early morning fasting patient, because in postprandial state there is increase in the blood creatinine and urine level (10% to 40%).2-hours collection of the urine, also correlate with the 24-hours of the urine.Collect the blood in the mid of urine collection.Refrigerate the urine during collection or keep it on ice.When 24 hours are completed, then empty the bladder, last urine sample in the same urine container. When starting urine collection note the time and discard the first sample of urine.24 hours of urine is collected along with serum (clotted blood 3-5ml).

Creatinine clearance pcalc